Publication
We have developed novel technologies such as microfluidic islet chips and imaging chemical probes/bio-sensors to investigate the regulation of islet Ca
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Pancreatic α and β cells are globally phase-locked
Huixia Ren, Yanjun Li, Chengsheng Han, Yi Yu, Bowen Shi, …, Shufang Wu, Xiaojing Yang, Sneppen Kim, Liangyi Chen, Chao Tang
Nature Communications
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28 Jun 2022
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doi:10.1038/s41467-022-31373-6
Readily releasable β cells with tight Ca2+–exocytosis coupling dictate biphasic glucose-stimulated insulin secretion
Xiaohong Peng, Huixia Ren, Lu Yang, Shiyan Tong, Renjie Zhou, …, Tao Xu, Chao Tang, Zhixing Chen, Huisheng Liu, Liangyi Chen
Nature Metabolism
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26 Jan 2024
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doi:10.1038/s42255-023-00962-0
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2025
Somatostatin triggers local cAMP and Ca2+ signaling in primary cilia to modulate pancreatic β-cell function
Ceren Incedal Nilsson, Özge Dumral, Gonzalo Sanchez, Beichen Xie, Andreas Müller, Michele Solimena, Huixia Ren, Olof Idevall-Hagren
The EMBO Journal
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12 Feb 2025
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doi:10.1038/s44318-025-00383-7
2024
δ-α cell-to-cell interactions modulate pancreatic islet Ca2+ oscillation modes
Huixia Ren, Yanjun Li, Beichen Xie, Weiran Qian, Yi Yu, Tianyi Chang, Xiaojing Yang, kim sneppen, Liangyi Chen, Chao Tang
Cold Spring Harbor Laboratory
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22 Aug 2024
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doi:10.1101/2024.08.21.608986
PDX1+ cell budding morphogenesis in a stem cell-derived islet spheroid system
Jia Zhao, Shenghui Liang, Haoning Howard Cen, Yanjun Li, Robert K. Baker, …, Liangyi Chen, Yanmei Liu, Francis C. Lynn, James D. Johnson, Timothy J. Kieffer
Nature Communications
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13 Jul 2024
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doi:10.1038/s41467-024-50109-2
Remodeling ceramide homeostasis promotes functional maturation of human pluripotent stem cell-derived β cells
Huijuan Hua, Yaqi Wang, Xiaofeng Wang, Shusen Wang, Yunlu Zhou, …, Chao Tang, Zhongyang Shen, Cheng Li, Yuanyuan Du, Hongkui Deng
Cell Stem Cell
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01 Jun 2024
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doi:10.1016/j.stem.2024.04.010
Readily releasable β cells with tight Ca2+–exocytosis coupling dictate biphasic glucose-stimulated insulin secretion
Xiaohong Peng, Huixia Ren, Lu Yang, Shiyan Tong, Renjie Zhou, …, Tao Xu, Chao Tang, Zhixing Chen, Huisheng Liu, Liangyi Chen
Nature Metabolism
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26 Jan 2024
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doi:10.1038/s42255-023-00962-0
2023
Bright and sensitive red voltage indicators for imaging action potentials in brain slices and pancreatic islets
Yi Han, Junqi Yang, Yuan Li, Yu Chen, Huixia Ren, …, Beichen Xie, Mengying Deng, Yinghan Xiao, Jun Chu, Peng Zou
Science Advances
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24 Nov 2023
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doi:10.1126/sciadv.adi4208
A tool kit of highly selective and sensitive genetically encoded neuropeptide sensors
Huan Wang, Tongrui Qian, Yulin Zhao, Yizhou Zhuo, Chunling Wu, …, Chao Tang, Yingjie Zhu, Dayu Lin, Jiang-Ning Zhou, Yulong Li
Science
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17 Nov 2023
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doi:10.1126/science.abq8173
2022
Pancreatic α and β cells are globally phase-locked
Huixia Ren, Yanjun Li, Chengsheng Han, Yi Yu, Bowen Shi, …, Shufang Wu, Xiaojing Yang, Sneppen Kim, Liangyi Chen, Chao Tang
Nature Communications
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28 Jun 2022
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doi:10.1038/s41467-022-31373-6
A Multiclassifier System to Identify and Subtype Congenital Adrenal Hyperplasia Based on Circulating Steroid Hormones
Lei Ye, Zhiyun Zhao, Huixia Ren, Wencui Wang, Wenzhong Zhou, …, Zhihan Wan, Chao Tang, Shouyue Sun, Weiqing Wang, Guang Ning
The Journal of Clinical Endocrinology & Metabolism
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05 May 2022
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doi:10.1210/clinem/dgac271
Human pluripotent stem-cell-derived islets ameliorate diabetes in non-human primates
Yuanyuan Du, Zhen Liang, Shusen Wang, Dong Sun, Xiaofeng Wang, …, Cheng Li, Chao Tang, Zhongyang Shen, Xiaozhong Peng, Hongkui Deng
Nature Medicine
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01 Feb 2022
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doi:10.1038/s41591-021-01645-7
Cell-to-cell variability in inducible Caspase9-mediated cell death
Yuan Yuan, Huixia Ren, Yanjun Li, Shanshan Qin, Xiaojing Yang, Chao Tang
Cell Death & Disease
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10 Jan 2022
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doi:10.1038/s41419-021-04468-z
2021
Red‐ and Far‐Red‐Emitting Zinc Probes with Minimal Phototoxicity for Multiplexed Recording of Orchestrated Insulin Secretion
Junwei Zhang, Xiaohong Peng, Yunxiang Wu, Huixia Ren, Jingfu Sun, …, Yiwen Zhao, Shusen Wang, Chao Tang, Liangyi Chen, Zhixing Chen
Angewandte Chemie International Edition
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01 Dec 2021
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doi:https://doi.org/10.1002/anie.202109510
2020
Cellbow: a robust customizable cell segmentation program
Huixia Ren, Mengdi Zhao, Bo Liu, Ruixiao Yao, Qi Liu, Zhipeng Ren, Zirui Wu, Zongmao Gao, Xiaojing Yang, Chao Tang
Quantitative Biology
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01 Sep 2020
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doi:10.1007/s40484-020-0213-6
2014
Large-field high-resolution two-photon digital scanned light-sheet microscopy
Weijian Zong, Jia Zhao, Xuanyang Chen, Yuan Lin, Huixia Ren, …, Ming Fan, Zhuan Zhou, Heping Cheng, Yujie Sun, Liangyi Chen
Cell Research
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26 Sep 2014
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doi:10.1038/cr.2014.124